This modification is shared with tirzepatide and other modern incretin analogs, and is essential for achieving the extended duration of action required for once-weekly dosing
They use derivatives of different adenoviruses as vectors for reasons more specifically discussed in section Distinguishing features of vaccines independent of immunogen, as follows: CanSinohuman adenovirus 5 61 , Janssen-Johnson&Johnsonhuman adenovirus 26 19,62,63 , Oxford-AstraZenecachimpanzee adenovirus Y25 64,65,66
Then, you pick up either semaglutide or tirzepatide to take home for the month, depending on which is better for your unique body
16 and Supplementary Tables 115
Its almost always worst right after a dose increase and eases up as your body adjusts