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Persister cancer cells: Iron addiction and vulnerability to ferroptosis
I., Horton, R
Finally, current limitations and future prospects are proposed, with the aim of providing inspiration for targeted readers in the field
An example of this in relation to glutathione depletion is in acetaminophen (paracetamol) overdose, where the acute poisoning causes a severe and dramatic loss of cellular glutathione, especially in the liver
Berberine also leverages this pathway, activating the NRF2/HO-1/GPX4 axis to suppress ferroptosis (64)
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