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In 2015, before the FDA approved synthetic GLP-1s for weight loss and researchers linked them to cardiovascular, kidney, and lung function, Rodrigo Mansur, a psychiatrist at the University of Toronto, hypothesized that GLP-1 drugs might help treat mental illness

This convergence extends beyond energy sensing into the domain of inflammation and oxidative stress

Dysesthesia, or unusual skin sensations such as tingling or altered sensitivity, has been reported in newer retatrutide clinical trial data

2025 Sept 7;15(17):2264

Congressional legislation to change this exclusion has been proposed but not enacted as of May 2026