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Reductions of this magnitude are rare in addiction medicine and what's remarkable is that the finding came from drugs initially designed for diabetes, later repurposed for obesity and never intended to treat addiction

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For example, in patients with cardiovascular diseases, L-Carnitine can help improve exercise tolerance and reduce symptoms of angina and heart failure

Specifically, MACEs comprised myocardial infarction, stroke (either ischemic or hemorrhagic), and cardiac death, while MAKEs were defined by progression to stage 5 chronic kidney disease (CKD), end-stage kidney disease, or initiation of dialysis