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Recently, studies have identified loss of trimethylation at lysine 27 of histone H3 (H3K27me3) in a subset of malignant peripheral nerve sheath tumors reflecting inactivation of the polycomb repressive complex 2 (PRC2), resulting from inactivating mutations of its constituents SUZ12 or EED
These medications work by binding to intracellular GST and undergoing GST-mediated catalysis
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Testosterone directly stimulates muscle protein synthesis, particularly fast-twitch muscle fibers
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