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Compounded versions of the drugs may be riskier Kessler says compounded GLP-1s, which are often cheaper than brand-name drugs and can be ordered online, carry additional risks
Nissen expects tirzepatide to soon join the pure GLP-1 RAs with an FDA-approved indication for weight loss in addition to diabetes, although it may meet the same payer reluctance around reimbursement for weight loss that the pure GLP-1 RAs have
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Liu H et al
Specifically, effect estimates (MD [95% CI]) for tirzepatide 15 mg vs semaglutide 2.0 mg, tirzepatide 10 mg vs semaglutide 1.0 mg, and tirzepatide 5 mg vs semaglutide 0.5 mg were, respectively, as follows: 3.87 mmol/mol (8.22 to 0.48)
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