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Funding This research was supported by grants from the National Natural Science Foundation of China (No
Although N-acetylcysteine (NAC) directly influences the pool of extracellular cystine and intracellular cysteine via a series of plasmatic redox reactions, in order to be effective, intracellular cysteine precursors must be designed to enter erythrocytes rapidly and use high activity enzymes within erythrocytes to liberate cysteine (Whillier et al., 2009
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Engstrom, Preclinical and clinical evaluation of broccoli supplements as inducers of glutathione S-transferase activity, Clin
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