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A randomized, double-blind, placebo-controlled phase 2 trial in Denmark involving 64 adults at high fracture risk found that once-weekly subcutaneous semaglutide did not increase the bone formation marker P-PINP relative to placebo, but did increase bone resorption and led to reductions in lumbar spine and hip BMD, tibial cortical thickness, and body weight over 52 weeks [104]

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The dose landing in fat instead of muscle B12 is given as an intramuscular injection for a reason: muscle has the blood supply to absorb it steadily