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These receptors activate intracellular cascades mediated by gustducin, phospholipase C beta 2 (PLC2), inositol triphosphate (IP3), and Transient Receptor Potential Melastatin 5 (TRPM5), leading to the release of ATP as a neurotransmitter (2, 24, 47)

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adults conducted in spring 2026, finds that about 18% of American adults are using a GLP-1 medication, up from approximately 14% in 2025

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