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In addition, secretory immunoglobulin A limits bacterial contact with epithelial cells and promotes adaptive immune responses via Peyers patches [66]

For arthritis specifically, semaglutide has evidence from the STEP-9 knee osteoarthritis trial and studies on rheumatoid arthritis joint outcomes, while tirzepatide has shown roughly a 33% reduction in hsCRP and an 18% reduction in IL-6 (key inflammation markers) in meta-analyses

In the first 12 weeks, many new users notice calmer appetite signals, earlier fullness, or less interest in snacking