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Unlike oral supplements, an injection delivers vitamin B12 directly into the body without relying on digestive absorption which can be reduced by age, certain medications such as proton pump inhibitors or metformin, or gastrointestinal conditions

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An intramuscular injection is absorbed slower over a long time frame, says Dr

And recent findings show that participants on the highest dose of retatrutide lost an average of 28.7% of their body weight over 68 weeks