The clinical literature on GLP-1 medications initially worried me because so many studies showed significant lean mass losses alongside the fat reduction
Potential long-term risks include pancreatitis, gallbladder disease, lean muscle mass loss, and early worsening of diabetic retinopathy with rapid glycaemic improvement
Even without a medical need for weight loss, we can work with patients toward an informed approach that respects their bodily autonomy and recognizes their societal discord and experiences living in larger bodies
In this respect, the dual agonist effect of tirzepatide seems to give it a superiority on semaglutide, with a greater decrease (more than 2%) in glycated hemoglobin (A1c), a marker of chronic hyperglycemia (Figure 4)
Take 3.5 grams twice daily after meals, mixed with at least 200ml of water and consumed immediately, followed by another glass of water