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Compared to GLP-1 agonists GLP-1 receptor agonists like semaglutide and tirzepatide have become extremely popular for weight loss
There is also a longevity fervor now, with longevity clinics, longevity companies (recently reviewed here), and longevity doctors
Factors like your age can play a role
This remarkable selectivity stems from 5-amino-1MQs specific interaction with the nicotinamide-binding pocket of NNMT, rather than the SAM-binding site common to many methyltransferases
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