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934 Recent studies have shown increased expression of elabela and APJ in neurons after cerebral I/R injury, with typical morphological and molecular features associated with ferroptosis in neurons, such as mitochondrial shrinkage, iron, and MDA accumulation, upregulation of ACSL4 and ALOX15, and downregulation of GPX4 and xCT

Oxidative stress is a major factor that leads to cell aging

Yehia R, Saleh S, El Abhar H, Saad AS, Schaalan M

H2S Supplementation An emerging candidate with potential effects in I/R field is the biological agent named hydrogen sulfide (H2S)

Drug Metab Rev 36 , 279299, doi: 10.1081/DMR-120034001 (2004)