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Knockdown of BCAT1 causes accumulation of -KG, promoting EGLN1-mediated HIF1 protein degradation and leukemia-initiating arrest (Raffel et al., 2017)

In intracellular selenium metabolism, selenium must be converted into Sec for selenoprotein translation

While various cell membrane lipids may undergo oxidation, the peroxidation of polyunsaturated fatty acids (PUFAs) in phospholipids by lipoxygenases (ALOXs) appears to be particularly important for ferroptosis [23]

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For spray formulations that omit benzyl alcohol entirely (some do, to avoid nasal irritation), microbial contamination adds to the degradation risk