The randomized, double-blind study demonstrated statistically significant improvements in blood sugar control at all tested doses, along with meaningful weight loss outcomes at the 14 mg dose compared to the placebo group. High-dose oral semaglutide has since demonstrated more substantial results
"Weight care is at a critical inflection point with unprecedented consumer demand, but limited options for personalized treatment that fit individual lifestyles," said Found Chief Medical Officer Rekha Kumar, MD, MS, former Medical Director of the American Board of Obesity Medicine
This keeps you within comfortable syringe range with room for small measurement variations
You should be under medical supervision if you really want to change your dose
In their paper on the study, published in JAMA Ophthalmology , the researchers noted that the substantially increased risk of NAION observed in patients on semaglutide appears not to be due to differences in baseline characteristics between the cohorts. They proposed the possibility that expression of the GLP-1 receptor in the human optic nerve and GLP-1 RA-induced enhanced sympathetic nervous system activity might influence optic nerve head perfusion and potentially increase the risk of NAION. Another notable finding was that the greatest risk of NAION appeared to be within the first year following the prescription of semaglutide, a temporal association that supports a potential drug-induced risk of NAION, the researchers pointed out