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For the butyrate producers, oral administration of Clostridium butyricum to mice lacking the leptin receptor, or to mice on HFD injected with streptozotocin to induce diabetes, was shown to improve oral glucose tolerance and insulin levels, and to increase the abundance of butyrate producers and fecal butyrate levels (96)

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Fat tissue contains aromatase enzymes that convert testosterone into estrogen, creating a cycle where excess body fat leads to lower testosterone, which promotes additional fat accumulation