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In the STEP-1 clinical trial, adults using semaglutide 2.4 mg weekly with lifestyle intervention lost an average of 14.9% body weight over 68 weeks, compared to 2.4% in the placebo group

doi: 10.1007/s00264-016-3146-y 13 SiYWangCGuoYYinHMaY

These metabolic improvements are consistent with the known lipolytic and lipid-regulatory effects of GH acting on hepatocytes and adipocytes, and are supported by retrospective analyses of the Phase 3 datasets

GLP-1 medicines may increase hypoglycemia risk when combined with insulin or sulfonylureas and may delay stomach emptying, affecting absorption of some oral medicines

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