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The mechanism is not fully understood, but theories include: Changes in blood flow to the optic nerve Rapid weight loss affecting ocular circulation Metabolic changes affecting eye health Legal Development: Vision loss cases are being consolidated into a separate MDL (MDL 3163) also overseen by Judge Marston

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Maintaining adequate hydration is paramount, particularly given semaglutide's gastrointestinal side effects

The drug performed better on all secondary endpoints as well, including a greater percentage of people losing at least 15% of their weight (roughly a third of those on the highest dose achieved this)