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NF-B, the master transcriptional regulator of pro-inflammatory gene expression, is activated downstream of TNF receptor and IL-1 receptor signaling

PMID: 16702333 | DOI: 10.1093/jn/136.6.1636S [13] Kumar P, Osahon OW, Vides DB, et al

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Although there is a relationship between low vitamin B 12 levels and cognitive decline, clinical studies - including those involving people with Alzheimer's disease - have not shown improvement in cognitive function, even doses of vitamin B 12 as high as 1000 micrograms per day