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Dihexa mimics HGF and activates the c-Met receptor directly
1) results in increased release of IL-1 and TNF-, which enhances SERT expression and activity in astrocytes and, therefore, increases reuptake and degradation of 5-HT to the metabolite 5-hydroxyindoleacetic acid (5-HIAA), thereby reducing extracellular levels of 5-HT [271, 285,286,287,288]
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