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Two 16-week phase 1 trials, one in subjects with obesity and another with T2D, shows significant reductions in body weight and HbA1c, respectively ( 2 without T2D demonstrates mean body weight losses of 6.8%, 13.6%, 16.7%, 18.7%, and 2.0% with 0.6 mg, 2.4 mg, 3.6 mg, 4.8 mg, and placebo, respectively ( 2 treated with survodutide 0.3, 0.9, 1.8, 2.7 mg weekly, 1.2 mg and 1.8 mg twice weekly, compared to semaglutide 1.0 mg weekly or placebo shows mean HbA1c percentage point reductions of 0.9, 1.5, 1.7, 1.6, 1.6, 1.7, 1.5, and 0.2, respectively, as well as mean body weight reductions significantly greater than placebo at all treatment doses, the highest being 8.7% for the 1.8 mg twice a week dose ( 3.5.4 Cotadutide Cotadutide is a GLP-1 and glucagon receptor co-agonist administered subcutaneously once daily

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However, landmark cardiovascular and kidney outcome trials of GLP-1RAs excluded T1D populations 6,7

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