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TRANQUILLO and TRANQUILLO 2 together enrolled 2,174 patients across 271 sites worldwide, the largest Phase 3 program to date for an oral systemic therapy in this indication
Available from: Frontiers Hlscher C
Proper technique ensures consistent absorption and reduces injection-site reactions that affect up to 30% of patients in clinical trials
2023;19:e1011057
The brain-access hypothesis and why it is contested One influential hypothesis for making sense of these mixed results, advanced by Christian Holscher, proposes that neuroprotective efficacy tracks a compounds ability to reach the brain
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