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When antibiotics, particularly sulphur drugs, are used for extended periods, the normal synthesis of Folic acid in the gut will be reduced and the requirements for Folic Acid are increased.

Clinically, this manifests as peripheral neuropathy, characterized by numbness, painful tingling, burning sensations in the extremities, and eventual loss of motor function

The compound has been investigated in adipocyte-research and metabolic-disease research contexts where elevated NNMT activity has been linked to insulin resistance and adipose-tissue dysfunction

Water retention is another common side effect of stimulating the GH pathway, though its a worthwhile tradeoff compared to the increased strength and energy you experience