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Nutrition 84 , 111119 (2021)

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Thyroid cancer in family members raises concerns

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There is also an energy consideration

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Glucagon-Based Multi-Agonist Approaches for Metabolic Diseases Molecular Metabolism Preclinical characterization of LY3437943 (retatrutide) showing tri-agonism at GIP/GLP-1/glucagon receptors produced superior weight loss, improved hepatic steatosis, and enhanced energy expenditure versus dual agonists

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However, doctors warn peptide use from these unverified sources is a dangerous gamble

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