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Palmitoylation is a reversible form of lipidation in which a saturated fatty acid, palmitic acid, is enzymatically attached to a free cysteine residue near the protein-lipid interface, forming a thioester linkage with the cysteine residue[37]
Under oxidative conditions, Nrf2 escapes Keap1-mediated ubiquitination and translocates into the nucleus, where it induces the expression of antioxidant genes involved in glutathione (GSH) synthesis, NADPH production, and cellular detoxification [34]
Reactive oxygen species and oncoprotein signaling-a dangerous liaison
This is due in part to its proven efficacy in treating type 2 diabetes and obesity, conditions that affect 14.7% and 41.9% of Americans, respectively
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