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In humans, the published evidence includes a retrospective series in which 7 of 12 people reported prolonged pain relief after intra-articular knee injection
Yang J, Huang C, Wu S, Xu Y, Cai T, Chai S, et al
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224 The lysine deacylase activity of SIRT4 is involved in the control of leucine metabolism and insulin secretion through regulating the acylation status of enzymes in these pathways
Int J Dev Neurosci 31:2124 Ribas GS, Manfredini V, de Mari JF, Wayhs CY, Vanzin CS, Biancini GB, Sitta A, Deon M, Wajner M, Vargas CR (2010) Reduction of lipid and protein damage in patients with disorders of propionate metabolism under treatment: a possible protective role of l-carnitine supplementation
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