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At the present level of our knowledge, it is safe to conclude that the orobuccal route can be used for treatment of hyperpigmentation with glutathione GSH at a dose of 10040050 mg per day for periods of between 10 and 12 weeks, depending upon indication, and it is hoped the treatment can be repeated to maintain effect

doi: 10.2147/DDDT.S308713 31 WangGYinYLvRLingXCaoHLiuHet al

The in vitro and in vivo anti-tumor results also revealed that D/S@SPMM nanocomposites may be effective and attractive in vivo application prospects

However, safety and efficacy depend heavily on choosing a qualified practitioner and adhering to recommended guidelines