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The evidence now says yes, and it is stronger than it was a year ago
Abstract Sodium-glucose cotransporters inhibitors (SGLT2-i) and GLP-1 receptor agonists (GLP1-RA) are glucose-lowering drugs that are proved to reduce the cardiovascular (CV) risk in type 2 diabetes mellitus (T2DM)
PMC (PMC5632578) (2017) 9
in fact, at the high glucose load AUC insulin was increased only approximately twofold in GIP receptor KO mice compared to zero glucose administration, whereas it was increased six times in wildtype mice
Its effectiveness is underscored by clinical trials demonstrating significant weight loss outcomes
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