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Taylor & Francis, Washington, pp pp

This efficient intracellular release mechanism, combined with the membrane-permeable nature of the payload, is critical for mediating a potent bystander effect, allowing it to diffuse into and kill adjacent cancer cells that may have heterogeneous or low HER2 expression, thereby overcoming a key mechanism of tumor resistance [55]

Step 2: Choose a High-Quality Format Avoid standard oral capsules that likely won't survive digestion

To induce tumor regression, mice were placed back on a diet containing 200 mg/kg doxycycline, ad libitum feeding

Briefly, the treated cells were seeded at a precise density for overnight culture, washed with basic medium, and equilibrated at 37 C for 1 h