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Safety considerations to keep in mind Vitamin B12 injections are water-soluble, meaning excess amounts are typically excreted by the body

Severe deficiency : Weekly or biweekly injections may initially be required to correct anemia and neurological symptoms

Vitamin B12, Mayo Clinic, Vitamin B12, Fact Sheet for Consumers, National Institutes of Health, Office of Dietary Supplements, Pernicious anemia, Cleveland Clinic, Ganipisetti VM, Naha S

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While your cells begin utilizing the nutrient within hours, it typically takes a day or two for that biological activity to translate into a noticeable physical boost. Can you get too much B12