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GPR43 is distributed in adipose tissue, bone marrow, spleen, pancreas, peripheral blood mononuclear cells, small intestine, and mammary gland, while GPR41 is distributed in various tissues, especially in immune cells

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The other two are approved for managing type 2 diabetes, but are commonly prescribed off label for weight loss

For energy expenditure Survodutide increases total energy expenditure through glucagon receptor activation, a unique advantage