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Nevertheless, the entry of peripheral ghrelin into the brain is limited and potentially binds only to areas of the brain that are less protected by the bloodbrain barrier like the arcuate and the area postrema in the brain stem (Banks et al., 2002

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In Study 3 and Study 4, adverse reactions were similar to those reported in the two pooled ZEPBOUND clinical trials (Study 1 and Study 2)

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Physiol Behav 206:232242 Bruns VN, Tressler EH, Vendruscolo LF et al (2024) IUPHAR review-Glucagon-like peptide-1 (GLP-1) and substance use disorders: an emerging pharmacotherapeutic target