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A 5-year longitudinal study showed that FTO gene polymorphisms can lead to premature rebound of ghrelin (an appetite-promoting hormone) and a hypersensitive brain response to food stimuli, thereby weakening the appetite-suppressing effect of weight loss interventions [79]
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Semaglutide might be better for those concerned about cost, side effects, or underlying metabolic conditions, given its longer real-world data and gentler side effect profile
When people on TikTok say they're "microdosing" semaglutide at 0.25 mg per week, they are, in many cases, simply taking the FDA-approved starting dose of Ozempic
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