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Clinical signs of B12 deficiency include nausea, vomiting, loss of appetite, poor absorption of food (malabsorption syndrome), constipation, gas, weight loss, fatigue, lethargy, abdominal pain, and diarrhea

Ghrelin, referred to by researchers as the hunger hormone , is believed to regulate the release of growth hormone by activating the Growth Hormone Secretagogue Receptor type 1a (GHS-R1a) in pituitary cells

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