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PDE5 inhibitors are used cautiously in this population because sildenafil and tadalafil are extensively metabolized by hepatic CYP3A4, and their clearance is reduced 2- to 3-fold in Child-Pugh B cirrhosis
How Protein Prevents Muscle Loss Higher protein intake during calorie restriction preserves lean muscle mass
Mechanisms underlying the rapid degradation and elimination of the incretin hormones GLP-1 and GIP
Alongside an expanding pipeline, innovation is accelerating through new mechanisms of action (e.g., GIP/GLP-1 dual agonists, amylin analogs, and small molecules like orforglipron) and diversified routes of administration such as orals and ultra-long acting injectables
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