IM injections present some risks: haematoma, for example, or nerve damage during injection
However, STEP 1 extension concluded that 1-year withdrawal of semaglutide results in regain of two-thirds of prior weight loss [97], highlighting that withdrawal of semaglutide results in weight regain which may be problematic in older adults who are already using polypharmacy approaches for comorbid disease
Front Endocrinol (Lausanne) 14:1240263 Sattar N, Neeland IJ, Dahlqvist Leinhard O, Fernandez Lando L, Bray R, Linge J et al (2025) Tirzepatide and muscle composition changes in people with type 2 diabetes (SURPASS-3 MRI): a post-hoc analysis of a randomised, open-label, parallel-group, phase 3 trial
Anxiety 32 , 594604 (2015)
Reduce Your Exposure to Toxins During a Herxheimer reaction, ongoing exposure to toxins may aggravate your symptoms and delay recovery