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[15] Serious but infrequent events-such as angioedema, bronchospasm, hypotension, or urticaria-reflect IgE-mediated hypersensitivity and may require desensitization or substitution with hydroxocobalamin

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The experiment included detailed clinical, morphological, and histological assessments to determine the degree of joint degeneration and recovery following different intra-articular treatments [1]

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