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This modulation occurs by regulating the spinal dorsal horn microglial pathway through GLP-1R activation, leading to alterations in spinal excitatory synaptic transmission under neuropathic pain conditions 13,14,15,16,17,18

doi: 10.1371/journal.pone.0126003 37 XuGKanetoHLopez-AvalosMDWeirGCBonner-WeirS

Whether this pattern persists beyond 52 weeks, whether it is dose-dependent, and whether it is reversible upon discontinuation of therapy are questions that remain unanswered and need to be addressed in larger, longer-duration trials