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Expression of sigma receptors in human cancer cell lines and effects of novel sigma-2 ligands on their proliferation [Doctoral Thesis]

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In PDAC tissue samples, the relative concentration of 5-OP was negatively associated with overall survival (OS) ( p = .04*) and high stage (III-IV) ( p = .007**)

This substitution may potentially increase the resistance of the peptide to enzymatic degradation and improve its stability