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Some people who have GI side effects on semaglutide tolerate tirzepatide well, and the reverse happens too

Planned surgery or procedures requiring sedation or anaesthesia

There are also risks to taking the drugs for people with disordered eating, especially since patients are not evaluated for these disorders when prescribed GLP-1 drugs

For those given in-office (unlikely for these drugs), it could theoretically be medical

By altering mesolimbic dopaminergic reward pathways, the therapy appears to influence alcohol-related responses at both behavioural and neural levels, supporting the need for further clinical investigation in individuals with problematic alcohol use