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Mechanistic analyses revealed that cotadutides enhanced hepatic benefits were associated with increased mitochondrial -oxidation capacity, improved mitochondrial respiratory chain function and more pronounced suppression of de novo lipogenesis enzymes

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(2) Sirt1 and Sirt3 preferentially remove the acetyl group over the butyryl group, whereas Sirt2 and Sirt6 preferentially remove the butyryl group over the acetyl group (acyl group-selectivity between acetyl versus butyryl group)