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If tirzepatide provides meaningful anti-inflammatory benefit, discontinuation could lead to a rebound in inflammatory markers as weight regain occurs and metabolic health deteriorates

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The most common side effects are gastrointestinal symptoms nausea, vomiting, diarrhea, and constipation

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Weight regain risk during the transition Research consistently shows that approximately two-thirds of patients regain weight when they stop GLP-1 receptor agonist therapy