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For example, the general applications of adeno-associated virus-based gene therapy are hampered by pre-existing humoral immune responses against the viral vectors [350,351,352], which for some viral serotypes occur in up to 60% of the population because of early-life infections [353, 354]

doi: 10.1007/s40618-019-01018-5 143 ZhangW.XuJ

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