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The decision to maintain or increase the dose should be based on individual treatment goals, clinical response, and tolerance to adverse effects

While glutathione is generally considered safe, individual responses can vary

(2024, September) Retatrutide is a novel triple-agonist targeting GLP-1, GIP, and glucagon receptors, showing in phase 2 trials that it can deliver remarkably large weight losses (up to ~24% over 48 weeks in people with obesity) along with strong improvements in HbA1c, lipid profiles, liver fat (in NAFLD), insulin sensitivity, and other cardiometabolic markers

Another drug Tamoxifen, that was originally known for its ability to increase fertility, was repurposed for breast cancer therapy

Degradation of the incretin hormone glucagon-like Peptide-1 (GLP-1) by enterococcus faecalis metalloprotease GelE