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Those chasing strength or fat-loss goals value steady energy over quick spikes

[6] Because NAD + -dependent enzymes are involved in DNA repair, protein deacetylation, stress responses, mitochondrial function, and cellular signaling, NNMT-related changes in NAD + availability should be interpreted in a pathway-specific manner rather than as a simple beneficial-or-harmful binary

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After initial repletion, a maintenance dose is given, often 1,000 mcg intramuscularly every month or every 2 to 3 months, to prevent recurrence of deficiency

This makes it easier to keep B12 levels up