A meta-analysis in PLoS ONE (2014) showed that polymorphisms in GSTM1 and GSTT1 genes (null genotypes) are associated with increased cancer risk due to reduced detoxification capacity
References: NIH Office of Dietary Supplements Carnitine Fact Sheet NCBI Carnitine: Overview and Function Siliprandi et al
By forming nonreactive molecules, Glutathione neutralizes hydrogen peroxide as well as oxygenated radicals that have disruptive effects on lipids, proteins, enzymes, and cellular DNA.
[2] In these studies, the molecule has been observed to enhance angiogenesis in the nervous system, to potentially stimulate nerve outgrowth, and decrease inflammation in the central nervous system
Defined: Glutathione Glutathione (GSH) is an important antioxidant in plants, animals, fungi, and some bacteria and archaea, preventing damage to important cellular components caused by reactive oxygen species such as free radicals, peroxides, lipid peroxides, and heavy metals.[2] It is a tripeptide with a gamma peptide linkage between the carboxyl group of the glutamate side-chain and the amine group of cysteine (which is attached by a normal peptide linkage to a glycine)
