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Excretion Pathways Elimination occurs through both renal and hepatic routes: Primary urinary excretion accounting for approximately 53% of administered dose for GLP1 Fecal elimination contributing approximately 19% of dose excretion Minimal intact peptide in urine (approximately 3.1% for GLP1
Mitochondrial overload and incomplete fatty acid oxidation contribute to skeletal muscle insulin resistance
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Beyond mtROS, other danger signals including ATP, crystalline substances, and membrane damage also contribute to NLRP3 activation in the hyperglycemic, AGE-rich, and oxidative DW microenvironment (Wang et al., 2025a)
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