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In addition, our data unambiguously documented that the effects of this and other multi-functional analogs on body weight and food intake are not merely due to food aversion or malaise linked to gastrointestinal distress, regarded as one of the main side-effects of GLP1-based therapy in humans 49

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Early pharmacology studies characterized it as a ghrelin-receptor agonist with selective growth-hormone-releasing activity in the experimental systems studied