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Within this framework, glucagon-like peptide-1 (GLP-1) receptor agonists (RAs), originally developed for the treatment of type 2 diabetes (T2D), have recently shown cardioprotective effects beyond their role in glycaemic control

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For example, post-radiation cancer cells suppress DNA damage sensing by hijacking caspase-9 signaling, whereas tumor-derived mtDNA can activate intrinsic DNA-sensing pathways

Unlike endogenous GHRH, Hexarelin has a distinct structure and dual-site activity, acting at both the hypothalamus and pituitary